Phosphatidylinositol 3-Kinase Class III
Homo sapiens (Human)
Phosphotidylinositol 3-kinase
catalytic subunit type 3
Accession Number: NP002638.2
Query ID: lcl|69869
Molecule Type: Amino acid
Query Length: 887 aa
Saccharomyces cerevisiae (Yeast)
Phosphotidylinositol 3-kinase
VPS34
Accession Number: P22543.1
Query ID: lcl|56498
Molecule Type: Amino acid
Query Length: 875 aa
Mus musculus (Mouse)
Phosphotidylinositol 3-kinase
catalytic subunit type 3
Accession Number: NP852079.2
Query ID: lcl|10817
Molecule Type: Amino acid
Query Length: 887 aa
Drosophila melanogaster (Fruit fly)
Phosphotidylinositol 3-kinase 59F
Accession Number: AAF47030.2
Query ID: lcl|72155
Molecule Type: Amino acid
Query Length: 949 aa
Arabidopsis thaliana (Plant)
Phosphotidylinositol 3-kinase
VPS34
Accession Number: NP176251.1
Query ID: lcl|61220
Molecule Type: Amino acid
Query Length: 814 aa
Basic Local Alignment Search Tool (BLAST) Analysis
The NCBI BLAST 2.0 program was used to produce the following BLAST results. For each of the BLAST searches performed, the 100 most similar proteins are presented. The E-values reported range between 0 and 7e-155, indicating that the matches are almost identical to the query protein sequence.
The results indicate that the same conserved domains are present across the species analyzed. These domains are related to the C2 superfamily, PI3Ka superfamily and PI3kc-like superfamily. The ATP binding site, catalytic loop and activation loop in the PI3Kc-like superfamily are conserved across the diverse range of species analyzed, which suggests that the function of PI3K Class III is similar in numerous species. Significant alignment scores for all the species analyzed signifies that the structure of PI3K Class III has been highly conserved throughout evolution.